Joaquin Phoenix and John C. Reilly are ‘The Sisters Brothers’ in Must-See First Trailer (VIDEO)

The independent western is, perhaps, the most burgeoning genre at the moment. Since The Coen Brothers revitalized the western with 2010's True Grit, many indie films have followed the same formula—character focused mix of comedy and shocking violence—to great success. 2015's Slow West is an absolute masterpiece of the genre, as is 2016's Hell or High Water, which is more contemporary, but no less western.

Now we have The Sisters Brothers, starring Joaquin Phoenix and John C. Reilly, and directed by Jacques Audiard (Rust & Bone, A Prophet). Phoenix and Reilly are two of the most gifted actors of their generation and excel at bouncing effortlessly between comedy and drama—though I will admit that Reilly is slightly harder to take seriously now, thanks to his alter ego Dr. Steve Brule.

They are joined in the cast by Nightcrawler co-stars Riz Ahmed and Jake Gyllenhaal, as well as a deep roster of great character actors like Rutger Hauer and Carol Kane. This is, far and away, my most anticipated film of the year. I'm in the bag for westerns as it is, but pairing up two great actors in a two-hander comedy/western? That's a magic formula for my money. Might as well just debit the cost of a ticket out of my bank account now. The Sisters Brothers hits theaters later this year.